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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AQP4
All Species:
27.27
Human Site:
T289
Identified Species:
50
UniProt:
P55087
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55087
NP_001641.1
323
34830
T289
D
N
R
S
Q
V
E
T
D
D
L
I
L
K
P
Chimpanzee
Pan troglodytes
XP_512074
323
34825
T289
D
N
R
S
Q
V
E
T
D
D
L
I
L
K
P
Rhesus Macaque
Macaca mulatta
XP_001097418
323
34819
T289
D
N
R
S
Q
V
E
T
D
D
L
I
L
K
P
Dog
Lupus familis
XP_855456
398
42980
T364
D
N
R
S
Q
V
E
T
E
D
L
I
L
K
P
Cat
Felis silvestris
Mouse
Mus musculus
P55088
323
34418
T289
D
N
R
S
Q
V
E
T
E
D
L
I
L
K
P
Rat
Rattus norvegicus
P47863
323
34462
T289
D
N
R
S
Q
V
E
T
E
D
L
I
L
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505227
324
34855
T290
N
S
Q
N
Q
V
E
T
D
D
L
I
L
K
P
Chicken
Gallus gallus
P28238
262
27053
P241
L
A
V
L
R
G
E
P
P
A
A
A
P
P
P
Frog
Xenopus laevis
NP_001124421
295
31792
V274
D
D
L
L
M
K
P
V
M
V
H
V
I
K
E
Zebra Danio
Brachydanio rerio
NP_001003749
320
34409
A291
D
S
Y
P
S
D
Q
A
Q
L
M
A
K
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V5Z7
245
25557
G224
I
A
G
G
L
L
A
G
I
I
Y
R
L
I
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193877
295
31953
D274
C
C
R
S
K
S
R
D
V
G
R
R
R
S
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZVX8
278
29482
H257
A
L
A
A
A
A
Y
H
Q
Y
I
L
R
A
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
77.6
N.A.
92.8
94.1
N.A.
84.8
38.3
69.9
61.6
N.A.
35.5
N.A.
N.A.
38.7
Protein Similarity:
100
100
99.6
79.4
N.A.
95.3
96.5
N.A.
92.9
55.1
79.2
76.1
N.A.
48.6
N.A.
N.A.
55.1
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
73.3
13.3
13.3
6.6
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
20
33.3
33.3
N.A.
13.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
50.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
8
8
8
8
8
8
0
8
8
16
0
8
16
% A
% Cys:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
62
8
0
0
0
8
0
8
31
54
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
62
0
24
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
8
8
0
8
0
8
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
8
8
8
54
8
8
0
% I
% Lys:
0
0
0
0
8
8
0
0
0
0
0
0
8
62
0
% K
% Leu:
8
8
8
16
8
8
0
0
0
8
54
8
62
0
0
% L
% Met:
0
0
0
0
8
0
0
0
8
0
8
0
0
0
0
% M
% Asn:
8
47
0
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
8
8
8
0
0
0
8
8
62
% P
% Gln:
0
0
8
0
54
0
8
0
16
0
0
0
0
8
0
% Q
% Arg:
0
0
54
0
8
0
8
0
0
0
8
16
16
0
0
% R
% Ser:
0
16
0
54
8
8
0
0
0
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
0
54
0
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
54
0
8
8
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
8
0
0
8
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _